血清Bcl-2、VEGF水平变化与食管癌患者TNM分期的关联性分析

Correlation analysis of serum VEGF,Bcl-2 levels and TNM staging in patients with esophageal cancer

目的:研究血清B细胞淋巴瘤2(Bcl-2)、血管内皮细胞生长因子(VEGF)水平变化与食管癌(EC)患者TNM分期的关联性。方法:选取我院EC患者74例(2019年3月~2020年3月),及同期健康体检者60例。均检测其血清Bcl-2、VEGF水平。比较EC患者、健康体检者血清Bcl-2、VEGF水平,对比EC患者不同临床特征血清Bcl-2、VEGF水平,并分析EC患者血清Bcl-2、VEGF水平与临床特征相关性。结果:EC患者血清Bcl-2、VEGF水平高于健康体检者(P<0.05);TNM分期为Ⅳ期、低分化程度、淋巴结转移患者血清Bcl-2、VEGF水平较高(P<0.05);经Spearman相关性分析,EC患者血清Bcl-2、VEGF水平与分化程度呈负相关,与TNM分期、淋巴结转移呈正相关(P<0.05)。结论:EC患者血清Bcl-2、VEGF水平表达异常,与分化程度、TNM分期、淋巴结转移等临床特征具有相关性,临床可通过监测其水平判断病情程度,具有重要临床意义。

Objective:To study the correlation between serum levels of B-cell lymphoma-2(Bcl-2)and vascular endothelial growth factor(VEGF)and TNM staging in patients with esophageal cancer(EC).Methods:74 cases of EC patients(March 2019 to March 2020)and 60 cases of healthy persons in the same period were selected.The serum levels of Bcl-2 and VEGF were detected.The serum levels of Bcl-2 and VEGF in EC patients and healthy persons were compared.The levels of serum Bcl-2 and VEGF in EC patients with different clinical characteristics were compared.The correlation between serum Bcl-2,VEGF levels and clinical characteristics was analyzed.Results:The serum levels of Bcl-2 and VEGF in EC patients were higher than those in healthy people(P<0.05);the serum levels of Bcl-2 and VEGF in patients with TNM stage IV,low differentiation and lymph node metastasis were higher(P<0.05);Spearman correlation analysis showed that serum Bcl-2 and VEGF levels were negatively correlated with differentiation degree,and positively correlated with TNM stage and lymph node metastasis(P<0.05).Conclusion:The abnormal expression of serum Bcl-2 and VEGF in EC patients is correlated with clinical features such as differentiation degree,TNM stage and lymph node metastasis.It is of great clinical significance to monitor the level of serum Bcl-2 and VEGF in patients with EC.