摘要
药源性肾损害是由药物不良事件(ADE)和药物不良反应(ADR)所致的药源性肾脏病,可导致急、慢性肾功能衰竭,严重降低患者生活质量,增加社会家庭经济负担,因而预防其发生具有重要的临床及社会意义。老年人是药源性肾损害的高危人群,老年人药源性急性肾损伤发生率为10%~65%。因此,明确老年人药源性肾损害的原因,研究老年人特殊的临床用药特点,加强老年人用药知识的教育和管理,对促进老年人用药安全、预防药源性肾损害极为重要。本文将就药源性肾损害的病理生理机制、危险因素、老年人发生药源性肾损害的原因及全-专联合预防策略展开讨论。
Drug-induced kidney injury(DKI)is a drug-induced kidney disease caused by adverse drug events or reactions,which may result in acute or chronic renal failure,seriously reducing the patients’quality of life,and increasing the economic burden on families and society.So the prevention of DKI has important clinical and social significance.The elderly is a high-risk group of DKI,among whom the incidence of DKI is about 10%to 65%.Therefore,identifying the causes of DKI,studying the special clinical medication characteristics,and strengthening medication education and management in the elderly are extremely important to promote medication safety and prevent DKI in this group.This review discusses the pathophysiological mechanism,risk factors,causes and general-specialty prevention strategies for DKI in the elderly.
作者
魏珊
刘英莉
WEI Shan;LIU Yingli(Department of Nephrology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)
出处
《中国全科医学》
CAS
北大核心
2021年第17期2140-2147,共8页
Chinese General Practice
基金
上海浦江人才计划(2016PJD032)
上海交通大学医学院附属第九人民医院临床研究计划(JYLJ2018011)~~。
关键词
药源性肾损害
老年人
药物不良反应
用药安全
预防策略
Drug-induced kidney injury
Aged
Adverse drug reactions
Medication safety
Prevention strategies
