5530例儿童7项呼吸道病毒检测结果分析

Analysis of seven respiratory viruses in 5530 children

目的了解河源地区儿童呼吸道病毒感染情况。方法采集5530例呼吸道疾病住院患儿鼻咽拭子,用直接免疫荧光法检测7种呼吸道病毒抗原(副流感病毒PIV1-3、呼吸道合胞病毒RSV、流感病毒FA/FB、腺病毒ADV)。结果呼吸道病毒检出阳性率为24.6%,单一、混合病毒阳性率分别为23.0%、1.6%。婴儿组病毒感染率最高,主要为RSV感染;ADV感染多见于学龄前期和学龄期儿童。毛细支气管炎的病毒检出率(51.8%)最高。春夏季病毒检出率低于秋冬季病毒感染率(P<0.01)。结论秋冬季是河源地区呼吸道病毒高发季节,RSV是住院婴幼儿呼吸道感染的主要病原体。

Objective To study the status of respiratory virus infection in children of Heyuan city.Methods Seven antigens of respiratory viruses including parainfluenza virus(PIV1-3),respiratory syncytial virus(RSV),influenza virus FA/FB and adenovirus(ADV)were determined by direct immunofluorescence in nasopharyngeal swabs of 5530 hospitalized children with respiratory diseases.Results The positive rate of respiratory viruses was 24.6%,with 23.0%of single virus and 1.6%of mixed infection.The positive rate of infants was the highest,with RSV being the main culprit,whereas ADV was more common in preschool and school children.The positive rate was the highest(51.8%)in bronchiolitis.The detection rate of viruses was lower in spring and summer than in autumn and winter(P<0.01).Conclusion There is a high incidence of respiratory virus infection in autumn and winter in Heyuan city.RSV is the main pathogen of respiratory virus infection in hospitalized infants.