癌症患者完全植入性静脉输液港血栓形成因素分析

Analysis of factors forming thrombosis with totally implantable access port in cancer patients

目的探讨癌症患者完全植入性静脉输液港血栓(TIAP)形成因素。方法选取某院肿瘤中心及肿瘤医院2019年1月—2020年2月139例癌症化疗TIAP患者临床资料,对患者一般资料、置管情况、TIAP形成情况进行分析,采用单因素和多因素Logistic分析TIAP形成的危险因素。结果经单因素分析发现,血栓组与无血栓组患者年龄、高凝状态、癌症分期、化疗方案的比例差异有统计学意义(P<0.05);多因素Logisic分析回归分析结果显示,患者年龄>55岁(OR=2.342,P=0.038)、高凝状态(OR=2.363,P=0.040)、临床分期处于Ⅲ~Ⅳ期(OR=2.485,P=0.027)、采取forfiri化疗(OR=2.771,P=0.013)为TIAP形成的4个重要独立危险因素。结论癌症化疗患者完全植入性静脉输液港血栓形成概率较大,如果治疗过程中将其作为主要的静脉通路时需给予对应的预防及监督措施,提升使用安全性,确保患者化疗顺利进行。

Objective To explore the factors forming thrombosis with totally implantable access port(TIAP) in cancer patients. Methods To select the clinical data of 139 cancer chemotherapy TIAP patients in a cancer center and cancer hospital from January 2019 to February 2020, analyze the general information of patients, catheterization, and TIAP formation, and use single-factor and multi-factor Logistic to analyze the risk factors of TIAP formation. Results Univariate analysis showed that there were statistically significant differences in the age, hypercoagulability status, cancer stage, and the proportion of chemotherapy regimens between the thrombosis group and the non-thrombosis group(P<0.05). Multivariate Logistic regression analysis showed that the patient’s age > 55 years old(OR =2.342, P =0.038), hypercoagulable state(OR =2.363, P =0.040), the clinical stage is in stage Ⅲ~Ⅳ(OR=2.485, P=0.027), and the use of forfiri chemotherapy(OR=2.771, P=0.013) were the four important independent risk factors of the TIAP formation. Conclusion The probability of thrombosis in cancer chemotherapy patients with fully implanted intravenous infusion port was relatively high. If it was used as the main venous access in the treatment process, corresponding preventive and supervision measures should be given to improve the safety of use and ensure the smooth progress of chemotherapy in patients.