循环肿瘤细胞簇促进血行转移的分子机制研究

Study on molecular mechanism of circulating tumor cell clusters promoting hematogenous metastasis

肿瘤转移是导致肿瘤患者死亡的重要原因,一旦发生转移,癌症将会变得更加难以治疗,许多研究已经观察到转移患者循环系统中存在循环肿瘤细胞(circulating tumor cells,CTCs),CTCs的检测可以用于预测临床结果,并可用于监测抗转移药物干预措施的疗效。CTCs在血行转移的过程中,偶尔会以团簇的形式出现,这些聚集的肿瘤细胞团与单个CTC相比,具有更高的转移特性,循环肿瘤细胞簇(circulating tumor cells clusters,CTC clusters)捕获技术的发展为肿瘤转移提供了新见解。该文讨论了CTC clusters形成的分子机制及其在肿瘤血行转移中的作用,并评价了其在治疗中作为生物标记物和治疗靶标的临床价值。

Tumor metastasis is an important cause of death in tumor patients.Once metastasis occurs,cancer will become more difficult to treat.Many studies have observed circulating tumor cells(CTCs)in the circulatory system of patients with metastasis.CTCs may occasionally appear in the form of clusters during the process of hematogenous metastasis.These aggregated tumor cell clusters have higher efficacy than the single CTC.The development of circulating tumor cell cluster capture technology provides new insights into tumor metastasis.The molecular mechanism of CTC clusters formation and their role in tumor hematogenous metastasis are discussed here,and their use as biomarkers and target in therapy is evaluated.