上海地区职业人群幽门螺杆菌感染现状及其影响因素

Helicobacter pylori infection prevalence and influencing factors in occupational populations in Shanghai

[背景]国内职业人群中幽门螺杆菌(HP)感染研究开展相对不足,且目前HP感染与血压、血糖、血脂、胃蛋白酶原等的关系尚不明确。[目的]调查上海地区职业人群的HP感染现状,并进行相关影响因素分析,为制定上海地区职业人群预防HP感染策略提供参考依据。[方法]以2019年1—12月期间在华东疗养院进行健康体检的上海地区各类单位职工为研究对象,采集符合条件者的基本资料和体检资料,包括年龄、性别、学历、婚姻状况、职业类别、血压以及血糖、血脂、胃蛋白酶原(PG)、幽门螺杆菌等实验室指标。描述不同人口学特征幽门螺杆菌的检出情况,采用logistic回归分析幽门螺杆菌感染的影响因素。[结果]在19062名职业人群中,HP阳性者5102例,检出率为26.8%。男性HP阳性检出率为28.3%(3406/12026)高于女性(24.1%,1696/7036)。多因素logistic回归模型显示:血压偏高(OR=1.158,95%CI:1.073~1.249)、空腹血糖浓度偏高(OR=1.142,95%CI:1.055~1.237)、甘油三酯浓度异常(OR=1.116,95%CI:1.037~1.201)、PGI/PGⅡ的值异常(OR=7.863,95%CI:6.951~8.894)的人群中HP感染风险增加;相比于≤35岁者,年龄≥52岁(OR=0.848,95%CI:0.766~0.937)的职业人群HP感染风险降低,女性的HP感染风险(OR=0.799,95%CI:0.732~0.872)较男性低。[结论]上海地区职业人群HP阳性检出率约是26.8%;血压、血糖、血脂、PG、年龄、性别等均与HP感染有关。

[Background]Research on Helicobacter pylori(HP)infection in occupational groups in China is relatively underdeveloped,and the relationships of HP infection with blood pressure,blood glucose,blood lipids,and pepsinogen are currently unclear.[Objective]This study investigates the prevalence of HP infection in occupational populations in Shanghai and related influencing factors,aiming to provide a reference for the formulation of strategies to prevent HP infection in the occupational populations in Shanghai.[Methods]The basic information and physical examination data,including age,gender,education,marital status,occupational category,blood pressure,blood glucose,blood lipids,pepsinogen,and HP,were collected from employees of various enterprises and institutions in Shanghai who ordered physical examinations at Huadong Sanatorium from January to December 2019.The positive rates of HP were estimated among the participants with selected demographic characteristics,and then the potential influencing factors of HP infection were evaluated by logistic regression analysis.[Results]Among the 19062 participants,there were 5102 cases of HP positive with an overall positive rate of 26.8%.The positive rate of HP in males28.3%(3406/12026)was higher than that in females24.1%(1696/7036).The multiple logistic regression models showed that high blood pressure(OR=1.158,95%CI:1.073-1.249),high fasting glucose concentration(OR=1.142,95%CI:1.055-1.237),abnormal triglyceride concentration(OR=1.116,95%CI:1.037-1.201),and pepsinogen I/pepsinogenⅡabnormalities(OR=7.863,95%CI:6.951-8.894)were all positively associated with HP infection risk;the risk of HP infection was reduced in the occupational population aged≥52 years compared to those under 35 years of age(OR=0.848,95%CI:0.766-0.937),and the risk of HP infection in women(OR=0.799,95%CI:0.732-0.872)was lower than than that in men.[Conclusion]The HP positive rate in the occupational populations in Shanghai is about 26.8%;blood pressure,blood glucose,blood lipids,pepsinogen,age,and gender are associated with HP infection.