点阵激光治疗瘢痕的机制研究进展

Research advances on the mechanism of fractional laser in treating scars

瘢痕是皮肤组织创伤异常修复的结果。近年来点阵激光被越来越广泛地应用于瘢痕治疗中,但其治疗机制尚不明确。目前研究表明点阵激光能够在靶组织中形成多个微热损伤区,诱导皮肤创伤修复反应,影响表皮层和真皮层细胞的功能,诱导血管和胶原蛋白变化,改变热休克蛋白、微小RNA、基质金属蛋白酶和转化生长因子β、碱性成纤维细胞生长因子等细胞因子的表达,促进药物运输,达到治疗瘢痕的效果。本文从细胞及组织学机制、分子机制及药物运输3个方面对点阵激光治疗瘢痕的机制进行综述。

Scars are the result of abnormal repair of skin tissue trauma.Recently,fractional laser is more and more widely used in the treatment of scars,but its mechanism is not clear.Studies have shown that fractional laser could produce multiple microthermal zones in target skin,induce wound repair responses,affect the function of epidermal and dermal cells,induce changes in blood vessels and collagens,and change the expression of heat shock proteins,microRNA,matrix metalloproteinases,cytokines such as transforming growth factorβ,basic fibroblast growth factor,and facilitate drug delivery,thus achieving the effect of treating scars.This article reviews the mechanism of fractional laser in treating scars from three aspects,including the tissue and cell mechanism,molecular mechanism,and drug delivery.