摘要
外泌体(exosomes)是一类直径50~150nm的细胞外膜泡,可以递送生物活性分子(如蛋白质、脂质、DNA、miRNA等)至靶细胞中,以发挥细胞间通讯作用。外泌体介导的细胞间通讯影响靶细胞的凋亡、侵袭、迁移、免疫应答及氧化损伤修复等功能。近年来外泌体研究在眼科学领域迅速开展,本文总结了在眼科疾病中外泌体相关研究的最新进展。
Exosomes are extracellular vesicles of sizes ranging from 50-150nm in diameter.Exosomes can deliver bioactive molecules(e.g.proteins,lipids,DNA,microRNA,etc.)into target cells which play an important role in cell-cell communication.Researches demonstrated that exosomes mediated cell-cell communication can impact cell apoptosis,invasion,migration,immune response and oxidative repair ability of recipient cells.Recently,researches on exosomes developed rapidly in the field of ophthalmology.This review summarized the latest research progress of exosomes in ophthalmic diseases.
作者
罗家伟
张国伟
康丽华
管怀进
Jia-Wei Luo;Guo-Wei Zhang;Li-Hua Kang;Huai-Jin Guan(Eye Institute, the Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China)
出处
《国际眼科杂志》
CAS
北大核心
2021年第5期805-809,共5页
International Eye Science
基金
国家自然科学基金资助项目(No.81974129)。
关键词
外泌体
眼科疾病
分子病理
细胞间通讯
研究进展
exosomes
ophthalmic diseases
molecular pathology
intercellular communication
research progress
