原发性闭角型青光眼脉络膜厚度的变化

Changes of choroid thickness in primary angle-closure glaucoma

目的:探讨原发性急性闭角型青光眼(APACG)、原发性慢性闭角型青光眼(CPACG)脉络膜厚度(CT)的变化及相关因素。方法:回顾性研究。选取APACG患者35例43眼,CPACG患者26例46眼和正常对照组46例81眼参与这项研究。EDI-OCT用于测量和比较APACG、CPACG及正常对照组黄斑中心凹下、距黄斑中心凹2mm鼻侧、颞侧、上方、下方的CT,分别标记为黄斑中心凹下脉络膜厚度(SFCT),鼻2mm(N 2mm)、颞2mm(T 2mm)、上2mm(S 2mm)、下2mm(I 2mm)。进行线性回归分析探讨CT的相关因素。使用Logistic回归模型分析CT与APACG、CPACG的关系。结果:APACG,CPACG和正常对照组在所有位点的CT均无差异(P>0.05)。所有位点的CT与眼轴长度(AL)呈负相关。N 2mm、I 2mm还与年龄、前房深度(ACD)呈负相关,SFCT与年龄、AL呈负相关(P<0.05)。多因素Logistic回归分析表明,S 2mm与APACG存在相关性(P=0.029),OR值和95%的置信区间为0.975(0.953,0.997)。各位点CT与CPACG无相关性(P>0.05)。结论:年龄、AL、ACD是CT的相关因素。S 2mm的变薄与APACG相关。然而,CPACG与各位点CT不存在相关性。

AIM:To investigate the changes and related factors of choroidal thickness(CT)in acute primary angle-closure glaucoma(APACG),and chronic primary angle-closure glaucoma(CPACG).METHODS:It was a retrospective study.A total of 35 patients(43 eyes)with APACG,26 patients(46 eyes)with CPACG and 46 patients(81 eyes)with normal eye condition and used as the control group in the study.EDI-OCT was used to measure and compare the foveal,nasal,temporal,superior and inferior CT of APACG,CPACG and normal control groups.The CT were labeled as subfoveal choroidal thickness(SFCT),nasal 2mm(N 2mm),temporal 2mm(T 2mm),superior 2mm(S 2mm),inferior 2mm(I 2mm).Linear regression analysis was used to explore the related factors of CT.Logistic regression analysis was used to evaluate the association between CT and presence of APACG and CPACG.RESULTS:There was no significant difference in CT of APACG,CPACG and normal control group(P>0.05).CT of all sites was negatively correlated with axial length(AL).N 2 mm and I 2 mm were also negatively correlated with age,anterior chamber depth(ACD),SFCT was negatively correlated with age and AL(P<0.05).Multivariate Logistic analysis showed that there was an association between S 2mm and APACG(P=0.029),the odds ratio(OR)and 95%confidence interval(CI)was 0.975(0.953,0.997).There was no association between CPACG and CT at all locations(P>0.05).CONCLUSION:Age,AL and ACD are the factors that related to choroidal thickness.It is also confirm that there is an association between decreased S 2mm and APACG.However,there is no correlation between CPACG and CT at all locations.