52种药食两用傣族药急性经口毒性评价

Evaluation of Acute Oral Toxicity of 52 Kinds of Edible Dai Medicine

目的:初步考察52种药食两用傣族药的急性毒性。方法:将52种药食两用傣族药参考惯用烹饪方式分别处理后,采用限量法和寇氏法开展小鼠急性经口毒性评价实验。结果:45种傣族药经过限量法实验,在较大剂量下未引起小鼠死亡,未见明显毒性。7种傣族药可测出半数致死量,均属于无毒级别。结论:多数药食两用傣族药不具备明显毒性,安全性较好,但仍建议进一步开展亚急性毒性或长期毒性实验研究以保障食品安全。

Objective:A preliminary investigation was made on the acute toxicity of 52 edible Dai medicine.Methods:After treating 52 kinds of edible Dai medicine with reference to conventional cooking methods,mice were used as experimental animals to carry out acute oral toxicity evaluation experiments using the limit test and the Korbor method.Results:It was observed in limited test that 45 kinds of Dai medicine did not cause animal death at larger doses and did not show significant toxicity.Median lethal dose of 7 kinds of Dai medicine was determined,all of which belonged to the non-toxic level.Conclusion:Most edible Dai medicine do not have obvious toxicity,but it is still recommended to carry out further subacute toxicity or long-term toxicity experimental research to ensure food safety.