摘要
咖啡酸、丹参素等小分子酚酸类成分有广泛的药理活性,丹参酚酸类成分在复方丹参制剂中发挥着主要的药效作用。据报道,小分子酚酸类成分在一定条件下发生自氧化,可引发自由基链反应。自由基还可通过复杂的机制偶联生成多种聚合物。其中,含1,4-苯并二噁烷结构的聚合物具有抗炎、抗肿瘤和抗病毒等药理活性。笔者对咖啡酸等小分子酚酸类成分的自氧化及自由基聚合机制、产物及药理活性进行综述,以期为阐明含小分子酚酸类成分相关产品的物质基础提供依据,为含1,4-苯并二噁烷结构的物质在化合物筛选、新药开发领域的应用提供参考。
Small-molecule phenolic acids such as caffeic acid and danshensu have a wide range of pharmacological activities,salvia phenolic acids have played a major role in compound salvia preparations.It is reported that the small-molecule phenolic acid component undergoes self-oxidation under certain conditions,which can trigger a free radical chain reaction.Free radicals can be coupled through a complex mechanism to produce a variety of polymers,of which polymers containing 1,4-benzodioxane structure have anti-inflammatory,anti-tumor,and anti-viral pharmacological activities.This article reviews the self-oxidation and free radical polymerization mechanism,products and pharmacological activities of small-molecule phenolic acid components such as caffeic acid,in order to provide references for clarifying the material basis of small-molecule phenolic acid-related products and the application of substances containing 1,4-benzodioxane structure in compound screening and new drug development.
作者
张倩倩
李思谦
周立红
张凤莲
章顺楠
吴春勇
ZHANG Qian-qian;LI Si-qian;ZHOU Li-hong;ZHANG Feng-lian;ZHANG Shun-nan;WU Chun-yong(School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China;National&Local United Engineering Laboratory for Traditional Chinese Medicine Advanced Manufacturing Technology,Tasly Pharmaceutical Group Co.,Ltd.,Tianjin 300410,China)
出处
《中国现代中药》
CAS
2021年第3期555-561,共7页
Modern Chinese Medicine
基金
2019年天津市智能制造专项。
关键词
咖啡酸
酚酸
小分子
自氧化
1
4-苯并二噁烷
caffeic acid
phenolic acid
small-molecules
auto-oxidation
1,4-benzodioxane