NPRL2在结直肠癌中的抗肿瘤作用

The anti-tumor effect of NPRL2 in colorectal cancer

结直肠癌(colorectal cancer,CRC)是全球最常见的癌症类型之一,其预后不佳提示明确CRC发病机制的重要性。既往研究表明,CRC的形成发展是多基因的,涉及多阶段变化,其中癌基因突变和肿瘤抑制基因(tumor suppressor gene,TSG)失活是促成CRC的重要因素。目前已经发现,氮通透酶调节因子-2(nitrogen permease regulator-like-2,NPRL2)作为抑癌基因在CRC中表达下调。NPRL2通过调节细胞周期进而抑制CRC的发生、发展,并且可以促进CRC细胞的凋亡和自噬,增强CRC细胞对多种化疗药物的敏感性。体内实验进一步验证了NPRL2在CRC中抗肿瘤和增强对化疗药物敏感性的作用。通过研究NPRL2在CRC中的抗肿瘤作用,有助于我们发现新的治疗手段。

Colorectal cancer(CRC)is one of the most common types of cancer in the world,and its poor prognosis indicates the importance of the pathogenesis of CRC.Previous studies have shown that the development of CRC is polygenic and involves multi-stage changes.Cancer gene mutation and tumor suppressor gene(TSG)inactivation are important factors in promoting CRC.It has been found that nitrogen permease regulator-like-2(NPRL2)is down-regulated in CRC as a cancer suppressor gene.NPRL2 inhibits the occurrence and development of CRC by regulating the cell cycle,promotes the apoptosis and autophagy of CRC cells,and enhances the sensitivity of CRC cells to a variety of chemotherapy drugs.In vivo experiments further verified the role of NPRL2 in anti-tumor and enhancing the sensitivity to chemotherapy drugs in CRC.This paper reviewed the anti-tumor effect of NPRL2 in CRC.