脑电生物反馈联合拉莫三嗪治疗慢性精神分裂症伴迟发性运动障碍患者的临床疗效分析

Clinical effects of EEG biofeedback combined with lamotrigine on chronic schizophrenia patients with tardive dyskinesia

目的探讨脑电生物反馈联合拉莫三嗪对慢性精神分裂症伴迟发性运动障碍(TD)患者的临床疗效。方法选取2018年6月—2020年6月在杭州市第七人民医院治疗的慢性精神分裂症伴TD患者82例。按照随机表法分为对照组和观察组,每组41例。两组患者维持原有抗精神疾病药物方案。对照组给予拉莫三嗪治疗,观察组在对照组基础上结合脑电生物反馈治疗。比较两组治疗8周后疗效,治疗前与治疗8周后异常不自主运动评定量表(AIMS)、β频段的脑电功率值、简明精神病量表(BPRS)评分和阳性和阴性症状量表(PANSS)评分变化。结果观察组总有效率高于对照组(P <0.05)。观察组治疗前后AIMS评分、BPRS评分及PANSS评分的差值大于对照组(P <0.05)。观察组治疗前后C3、C4、P3和P4点β频段的脑电功率值的差值大于对照组(P <0.05)。结论脑电生物反馈联合拉莫三嗪治疗慢性精神分裂症伴TD患者疗效良好,且可减轻患者迟发性运动障碍。

Objective To investigate the clinical effects of electroencephalographic(EEG) biofeedback combined with lamotrigine in the treatment of chronic schizophrenia with tardive dyskinesia(TD). Methods The 82 cases of chronic schizophrenia with TD in Hangzhou Seventh People’s Hospital from June 2018 to June 2020 were randomly divided into control group(41 cases) and observation group(41 cases). Both of the groups maintained the original antipsychotic drug regimens. The control group was treated with lamotrigine, and the observation group was treated with EEG biofeedback on the basis of the control group. The treatment course of the two groups was 8 weeks. The Abnormal Involuntary Movement Scale(AIMS) score, β-band EEG power value, Brief Psychiatric Rating Scale(BPRS) score and Positive and Negative Syndrome Scale(PANSS) score were compared between the two groups before and after 8 weeks of treatment. Results The overall effective rate in the observation group was higher than that in the control group(P < 0.05). The differences of AIMS, BPRS and PANSS scores before and after treatment in the observation group were higher than those in the control group(P < 0.05). Besides, the differences of EEG power values at C3, C4, P3 and P4 before and after treatment in the observation group were higher than those in the control group(P < 0.05). Conclusions EEG biofeedback combined with lamotrigine is effective in the treatment of chronic schizophrenia with TD and can alleviate the severity of TD.