胆碱对肝脏糖代谢的调控作用及机制

Regulation and Mechanism of Choline on Liver Glycometabolism

胆碱是动物饲粮中必不可少的营养素,在动物机体中以多种形式存在,可分别通过乙酸化、磷酸化和氧化的途径参与乙酰胆碱、磷脂酰胆碱、甲基供体的合成,并能改善动物的糖代谢。本文在现有相关文献的基础上,重点综述了胆碱调控动物肝脏糖代谢的研究进展,阐明胆碱对肝脏糖异生、糖氧化代谢、抗氧化能力和糖代谢疾病的影响,并将涉及的多条糖代谢信号传导通路构建形成调控网络,旨在为畜牧养殖和科学研究工作提供参考依据。

Choline is an essential nutrient in animal diets.It exists in various forms in the animal body and can participate in the synthesis of acetylcholine,phosphatidylcholine and methyl donors through the pathways of ac⁃etate,phosphorylation and oxidation,respectively.And it also can improve the level of animal glycome⁃tabolism.Based on the existing relevant literature,we focused on the research progress of choline regulating liver glucose metabolism in animals,and clarified the effect of choline on liver gluconeogenesis,glucose oxida⁃tion metabolism,antioxidant capacity and glucose metabolism diseases,which involved several signaling path⁃ways for glycometabolism.Finally,we combined these signaling pathways to form a regulation network.This review aimed to provide the reference for animal husbandry and scientific research.