辅助性T细胞17/调节性T细胞平衡调控炎症性肠病及其在动物生产上的应用

T Helper Cells 17/Regulatory T Cells Balance Regulation of Inflammatory Bowel Disease and Its Application in Animal Production

炎症性肠病(IBD)通常由易感基因、环境和免疫系统之间复杂的一系列相互作用引起,会造成肠道屏障机能紊乱。由白细胞分化抗原4阳性辅助T细胞(CD4+T)的2个子集辅助性T细胞17(Th17)和调节性T细胞(Treg)组成的平衡轴可以对IBD进行正负调节,Th17促进IBD,Treg抑制IBD。这种调控作用与多种信号传导通路有关。参考前人研究中利用各类饲料添加剂刺激Th17/Treg平衡及治疗IBD的报道,本文就Th17与Treg的分化、IBD的发病机理、Th17/Treg平衡相关信号通路以及基于Th17/Treg平衡开发饲料添加剂以调控IBD等方面进行综合阐述。

Inflammatory bowel disease(IBD)is usually caused by a complex series of interactions among sus⁃ceptible genes,environment and immune system,and usually causes disturbances in the intestinal barrier func⁃tion of the body.The balance axis composed of T helper cells 17(Th17)and regulatory T cells(Treg),two subsets of cluster of differentiation positive T helper cells(CD4+T),can positively and negatively regulate IBD,Th17 promotes IBD,and Treg inhibits IBD.This regulatory effect is related to a variety of signaling pathways.With reference to the reports of using various feed additives to stimulate Th17/Treg balance and treat IBD in previous studies,this article will focus on Th17 and Treg differentiation,pathogenesis of IBD,Th17/Treg balance related signaling pathways and the feasibility of developing feed additives to regulate IBD through Th17/Treg.