艾司西酞普兰联合心理疗法对焦虑症患者睡眠质量、生活质量和血清神经递质水平的影响

Effects of Escitalopram Combined with Psychotherapy on Sleep Quality,Quality of Life and Serum Neurotransmitter Levels in Patients with Anxiety Disorder

目的:探讨艾司西酞普兰联合心理疗法对焦虑症患者睡眠质量、生活质量和血清神经递质水平的影响。方法:选取2017年7月~2020年3月期间我院收治的焦虑症患者117例,随机分为对照组58例和研究组59例,对照组给予艾司西酞普兰治疗,研究组在对照组的基础上联合心理疗法,对比两组疗效、汉密尔顿焦虑量表(HAMA)、匹兹堡睡眠质量指数量表(PSQI)及健康调查简表(SF-36)评分、血清神经递质[5-羟色胺(5-HT)、去甲肾上腺素(NE)、髓过氧化物酶(MPO)和神经肽(NPY)]水平及不良反应。结果:治疗8周后,研究组的临床总有效率为88.14%(52/59),明显高于对照组的70.69%(41/58)(P<0.05)。研究组治疗8周后血清MPO水平低于对照组,5-HT、NE、NPY水平高于对照组(P<0.05)。研究组治疗8周后HAMA、PSQI量表评分低于对照组(P<0.05)。研究组治疗8周后精神健康、生理机能、躯体疼痛、社会功能、情感职能、活力、生理职能、健康状况评分均高于对照组(P<0.05)。两组不良反应发生率对比差异无统计学意义(P>0.05)。结论:艾司西酞普兰联合心理疗法治疗焦虑症患者疗效及安全性均较好,可有效改善患者焦虑症状、睡眠质量及生活质量,同时还可有效调节血清神经递质水平。

Objective:To investigate the effect of escitalopram combined with psychotherapy on sleep quality,quality of life and serum neurotransmitter levels in patients with anxiety disorder.Methods:117 patients with anxiety disorder admitted to our hospital from July 2017 to March 2020 were selected,and randomly divided into control group(58 cases)and study group(59 cases).The control group was treated with escitalopram,and the study group was combined with psychotherapy on the basis of the control group.The efficacy,Hamilton Anxiety Scale(HAMA)and Pittsburgh sleep quality index(PSQI)and short form of health survey(SF-36)scores,serum neurotransmitter levels[5-hydroxytryptamine(5-HT),norepinephrine(NE),myeloperoxidase(MPO),neuropeptide(NPY)]and adverse reactions were compared between the two groups.Results:8 weeks after treatment,the clinical total effective rate of the study group was 88.14%(52/59),which was significantly higher than that of the control group 70.69%(41/58)(P<0.05).8 weeks after treatment,the MPO levels of the study group were lower than those of the control group,and the 5-HT,NE and NPY level was higher than that of the control group(P<0.05).8 weeks after treatment,HAMA and PSQI scores of the study group were lower than those of the control group(P<0.05).8 weeks after treatment,the scores of mental health,physiological function,physical pain,social function,emotional function,vitality,physiological function and health status of the study group were higher than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Escitalopram combined with psychotherapy has good efficacy and safety in the treatment of patients with anxiety disorder.It can effectively improve the anxiety symptoms,sleep quality and quality of life,and effectively regulate the serum neurotransmitter levels.