^(125)I放射性粒子植入术后卡培他滨单药化疗联合二陈汤治疗晚期结直肠癌疗效分析

Efficacy of chemotherapy with single agent capecitabine combined with Erchen decoction for advanced colorectal cancer after^(125)I radioactive seed implantation

目的探讨二陈汤联合^(125)I粒子植入、卡培他滨单药化疗对晚期结直肠癌患者预后及生活质量的影响。方法选取2019年9月至2020年9月间广州市中西医结合医院收治的60例晚期痰湿内停证型结直肠癌患者,分为试验组和对照组,每组30例。所有患者行肿瘤^(125)I粒子植入、术后卡培他滨单药化疗,治疗组加用中医二陈汤治疗。比较两组患者治疗前后的疗效和生活质量。结果实验组治疗后肿瘤缩小百分率、癌胚抗原(CEA)下降程度、部分缓解率和客观缓解率均优于对照组,差异均有统计学意义(均P<0.05);对照组的疾病稳定率优于试验组,差异有统计学意义(P<0.05)。两组患者的完全有效率和疾病进展率比较,差异无统计学意义(P>0.05)。试验组治疗后癌痛缓解和生活质量评分改善程度均好于对照组,差异均有统计学意义(均P<0.05)。结论125 I粒子植入术后卡培他滨单药化疗联合二陈汤治疗晚期痰湿内停型结直肠癌患者,治疗效果优于单纯西医治疗,且能更好改善患者生活质量。

Objective To study the efficacy of Chinese medicine Erchen decoction combined with^(125)I seeds implantation and chemotherapy with capecitabine on the prognosis and quality of life in patients with advanced colorectal cancer.Methods A total of 60 advanced colorectal cancer patients with phlegmdampness and fluid retention syndrome were selected at Guangzhou Hospital of Integrated Traditional and West Medicine from September 2019 to September 2020.They were assigned to an experimental group and control group with 30 patients in each group.All patients received^(125)I radioactive seed implantation and chemotherapy with single agent capecitabine after the surgery.Apart from this,the experimental group received Erchen decoction.The treatment efficacy and quality of life were compared between the two groups before and after the treatment(all P<0.05).Results The percentage of tumor reduction,carcinoembryonic antigen(CEA)decreased,partial response and objective remission rate were significantly better in the experimental group than in the control group(all P<0.05).The disease stability rate in control group was superior to the experimental group(all P<0.05).There was no significant difference in complete efficacy rate and disease progression rate between the two groups(P>0.05),Improvement in cancer pain and qual-ity of life were better in the experimental group than in the control group after treatment(all P<0.05).Conclusion The efficacy of chemotherapy with single agent capecitabine combined with Chinese Medicine Erchen decoction after^(125)I radioactive seed implantation in patients with advanced colorectal cancer with phlegm-dampness fluid retention syndrome is better than single western medicine treatment,and the quality of life can be vastly improved.