河北省眼科医院近5年抗青光眼药物使用及变化趋势

Clinical use and the changing trend of anti-glaucoma medications in the Eye Hospital of Hebei Province in recent 5 years

目的分析我院门诊2012至2016年抗青光眼药物的使用情况及变化趋势,为临床用药提供参考。方法回顾性分析。收集2012年1月1日至2016年12月31日就诊于我院门诊的青光眼患者(共21969人次)的用药数据,了解其中不同局部抗青光眼药物的使用情况并分析其变化趋势。主要指标:药物种类,药物使用比例。结果β-肾上腺素能受体阻滞剂在2012年时的使用量占总抗青光眼药物量为60%,逐年降低,至2016年时降低为53.5%;拟胆碱能药物在2012年时量占总抗青药物的为11.7%,逐年下降,2016年时降低为8.7%;局部碳酸酐酶抑制剂在2012时使用率为28.6%,逐年下降,2015年时为24.5%,2016年时为26.8%;前列腺素类衍生物在2012年时使用量占总抗青药物的为11.6%,2016年时增加为15.7%;α2-肾上腺素能受体激动剂在2012年时使用率为25.2%,逐年上升,2016年时为43.8%。单一用药由2012年的66.0%,降为2016年的58.3%,2种药物联合使用由2012年的30.0%,增加为2016年的35.2%,3种药物联合使用由2012年的3.02%增加为2016年的5.89%,2012年至2016年4种药物联合使用率均低于1%,均无5种药物联合使用。结论近5年来,邢台地区抗青光眼治疗药物使用出现缓慢变化趋势。β-肾上腺素能受体阻滞剂、局部碳酸酐酶抑制剂和拟胆碱能药物缓慢下降,而前列腺素类衍生物缓慢上升,α2-肾上腺素能受体激动剂明显上升,其中β-肾上腺素能受体阻滞剂仍为常见抗青光眼用药中的最主要用药。联合用药比例呈现总体上升趋势,但超过九成的患者为1种或2种用药。

Objective To investigate and analyze the clinical use and changing trend of anti-glaucoma medication in the outpatient clinic of our hospital from 2012 to 2016,in order to provide reference for clinical medication.Methods Data on medication prescriptions for 21969 patients with glaucoma in our hospital from January 1,2012 to December 31,2016 were retrospectively analyzed.Main measurements of this study include the type and ratio of the medications.Results The use ofβ-adrenergic receptor blockers accounted for 60%of the total amount of anti-glaucoma medication in 2012,which decreased over the years,to 53.5% in 2016.The utilization rate of cholinergic medications was 11.7% in 2012,which decreased to 8.7% in 2016.The utilization rate of topical carbonic anhydrase inhibitor was 28.6% in 2012,which decreased to 24.5% in 2015 and increased to 26.8% in 2016.The use of prostaglandin derivative medications was 11.6% in 2012,and increased to 15.7% in 2016.The utilization rate of selectiveα2-receptor agonists was 25.2% in 2012,and increased over the years to 43.8% in 2016.Single medication use rate decreased from 66.0%in 2012 to 58.3%in 2016,combined use of two medications increased from 30.0% in 2012 to 35.2% in 2016,and combined use of three medications increased from 3.02% in 2012 to 5.89% in 2016.During the period of 2012-2016,the combined use rate of four medications was less than 1%,and there was no combined use of five medications.Conclusions During the recent five years,the utilization rate of anti-glaucoma medications in the Xingtai area changed slowly.The use ofβ-adrenergic receptor blockers,topical carbonic anhydrase inhibitor and cholinergic medications decreased slowly,while the use of prostaglandin derivative medications increased slowly,and the use of selectiveα2-receptor agnoists increased significantly.β-adrenergic receptor blockers still ranked first among common anti-glaucoma medications.The proportion of combined medication use showed a general upward trend,but over 90% outpatients were treated with 1 or 2 kinds of medications.