眼部抑制性免疫微环境与调节T细胞

Eye suppressive immune microenvironment and T-regulatory cells

眼睛的解剖结构、生理学和免疫学特性共同营造了眼部免疫特权,一旦炎症破坏了眼部抑制性免疫环境,则会引起不可逆的眼部组织损伤。角膜上皮细胞、色素上皮细胞等眼部驻留细胞通过产生包括TGF-β2、α-MSH、PD-1/PD-L1以及Fas/FasL在内的微环境调节因子来诱导调节T细胞的产生,从而抑制眼内炎症反应。通过研究免疫应答对炎性眼部疾病的影响不难发现,这些免疫负性调节因子及调节T细胞可作为治疗自身免疫疾病的潜在靶点。

The anatomical,physiological,and immunological features act in concert to foster the ocular immune privilege.Once the inflammation destroys the suppressive microenvironment,it can cause irreversible eye tissue damage.Ocular resident cells,like corneal endothelial cells and ocular pigment epithelial cells,induce T-regulatory cells to prevent activation of inflammation within the ocular tissue by producing negative regulators of inflammation which including TGF-β2,α-MSH,PD-1/PD-L1 and Fas/FasL.It is not difficult to find by studying the influence of immune response on inflammatory eye diseases,these negative regulators and T-regulatory cells can be used as potential targets for the treatment of autoimmune eye diseases.