腹型肥胖与女性脆性骨折发生风险的相关性

Association between abdominal obesity and risk of developing fragility fracture in females

目的探讨腹型肥胖与女性脆性骨折发生风险的关联性。方法根据腰围将200例体检女性分为腹型肥胖组110例(腰围≥80 cm)和非腹型肥胖组90例(腰围<80 cm),均随访1年。比较两组研究对象的脆性骨折发生率。采用多因素Logistic回归模型分析女性发生脆性骨折的影响因素。结果腹型肥胖组的脆性骨折发生率为39.09%(43/110),高于非腹型肥胖组的14.44%(13/90)(P<0.05),相对危险度为2.71。多因素Logistic回归分析结果显示,腹型肥胖、年龄>60岁、吸烟、饮酒以及已绝经是女性脆性骨折发生的危险因素(均P<0.05)。结论腹型肥胖女性的脆性骨折发生率高于非腹型肥胖女性,腹型肥胖可增加女性发生脆性骨折的风险,因此应重点关注这类人群脆性骨折的临床防治。

Objective To explore the association between abdominal obesity and the risk of developing fragility fracture in females.Methods A total of 200 women who underwent physical examination were divided into abdominal obesity group(110 cases with a waist circumference≥80 cm)and non abdominal obesity group(90 cases with a waist circumference<80 cm)according to their waist circumference,and both groups were followed up for one year.The incidence rate of fragility fracture of the subjects in the two groups was observed.The multivariate Logistic regression model was used to analyze the influencing factors of developing fragility fracture in females.Results The incidence rate of fragility fracture in the abdominal obesity group was 39.09%(43/110),which was higher than 14.44%(13/90)in the non abdominal obesity group(P<0.05),with a relative risk of 2.71.The results of multivariate Logistic regression analysis showed that abdominal obesity,age>60 years,smoking,drinking,and menopause were the risk factors of developing fragility fracture in females(all P<0.05).Conclusion Females with abdominal obesity have a higher incidence rate of fragility fracture as compared with females with non abdominal obesity,abdominal obesity might increase the risk of developing female fragility fracture.Therefore,the clinical prevention and treatment of fragility fracture should focus on such people.