微小RNA对阿霉素诱导心脏毒性保护作用的研究进展

Research progress on protection of microRNA against adriamycin induced cardiotoxicity

阿霉素(DOX)是一种具有强效抗肿瘤作用的蒽环类抗生素,其临床应用因其心脏毒性而受到限制,但其发病机制仍未完全了解。近年来,许多研究提出微小RNA(miRNA)在DOX诱导心脏毒性过程中有重要作用,它可调节心肌细胞的凋亡、自噬相关基因表达稳定性,现就近期miRNA的研究结果,尤其是miRNA在DOX诱导心肌细胞损伤分子机制以及与上下游相关基因的调节作用做一综述。miRNA可能成为DOX心脏毒性新的诊断性生物学诊断指标,miRNA激动剂或拮抗剂和外源性miRNA模拟药可能成为今后治疗DOX所致心脏毒性的新靶点。

Doxorubicin(DOX)is an anthracycline antibiotic with strong anti-tumor effect,Its clinical application is limited due to its cardiac toxicity,but its pathogenesis has still not been fully understood.In recent years,many studies have suggested that microRNA(miRNA)plays an important role in the process of DOX-induced cardiotoxicity,which can regulate the apoptosis of cardiomyocytes and the expression stability of autophagy-related genes.This review mainly reviews the recent research results of miRNA,especially the molecular mechanism of miRNA in DOX-induced cardiomyocyte damage and the regulatory role of upstream and downstream related genes.miRNA may become a new diagnostic biological diagnostic indicator for DOX cardiotoxicity,miRNA agonists or antagonists and exogenous miRNA mimics may become new targets for the treatment of cardiotoxicity caused by DOX in the future.