摘要
DNA X激活蛋白12(DNAX activation protein of 12 kDa,DAP12)是包含基于免疫受体酪氨酸激活基序(immune receptor tyrosine activated motif,ITAM)的I型跨膜衔接蛋白的成员。DAP12与髓样细胞触发受体2(trigger receptor expressed in myeloid cell 2,TREM-2)表达的触发受体形成分子复合物。牙周炎是口腔常见的一种慢性感染性疾病,牙周炎发生发展中,骨破坏和骨形成的调控信号通路会发生异常变化,而TREM-2/DAP12复合物在破骨细胞的生成和分化中起着重要的作用。本文总结了近年来TREM-2/DAP12复合物在牙周炎中作用的研究进展,以期为牙周炎的治疗提供新思路。
DAP12(DNA X activation protein of 12 kDa)is a member of a type I transmembrane cohesive protein containing an immune receptor tyrosine activated motif(ITAM).DAP12 forms a molecular complex with the trigger receptor expressed in myeloid cell 2(TREM-2).Periodontitis is a chronic infectious disease in oral cavity.During the development of periodontitis,abnormal changes will occur in the regulatory signaling pathways of bone destruction and bone formation,and the TREM-2/DAP12 complex plays an important role in the generation and differentiation of osteoclasts.This paper summarized the research progress of TREM-2/DAP12 complex in periodontitis in recent years,hoping to provide new ideas for the treatment of periodontitis.
作者
李琴
王佐林
LI Qin;WANG Zuolin(Shanghai Engineering Research Centre of Tooth Restoration and Regeneration,Department of Oral Implantology,School and Hospital of Stomatology,Tongji University,Shanghai 200072,China)
出处
《口腔颌面外科杂志》
CAS
2021年第2期110-113,共4页
Journal of Oral and Maxillofacial Surgery
