电化学催化下的多氟烷基化反应研究进展

Research Progress of Polyfluoroalkylation Reaction under Electrochemical Catalysis

氟化学已经在各行各业受到广泛应用,氟化学和有机化学的结合也遍地生花.由于将氟原子或氟基团引入到药物中具有重要意义,因此寻求一种有效的氟烷基化途径至关重要.随着电化学的发展,人们将电化学和氟烷基化反应进行了巧妙地结合.进而得到了更加安全、经济、环保并且高效的氟烷基化途径.在电化学指导下的氟烷基化反应途径,不仅在反应方式方面进行了革新,同样在底物普适性方面也具有优势.针对不饱和脂肪族化合物及其衍生物和芳香族化合物的电化学催化下的氟烷基化反应已经有诸多报道.根据底物的性质及其反应机理总结了电催化下氟烷基化方法的进展.

Fluorine chemistry has been widely used in all walks of life, and the combination of fluorine chemistry and organic chemistry is blooming everywhere. Since the introduction of fluorine atoms or fluorine groups into drugs is of great significance, it is essential to seek an effective fluoroalkylation pathway. With the development of electrochemistry, people combine electrochemistry and fluoroalkylation reaction skillfully. In turn, a safer, more economical, environmentally friendly and efficient fluoroalkylation pathway is obtained. The fluoroalkylation reaction pathway under the guidance of electrochemistry has not only reformed the reaction method, but also has advantages in terms of substrate universality. Fluoroalkylation of unsaturated aliphatic compounds their derivatives and aromatic compounds under electrochemical catalysis has been reported. According to the nature of the substrate and its reaction mechanism, the progress of electrocatalytic fluoroalkylation methods is summarized.