多组分参与的氟烷基化反应研究进展

Progress in Fluoroalkylation of Multicomponent

多组分参与的氟烷基化反应是当前有机氟化学研究的一个热点.在过去的几年里,由于新试剂新方法的不断涌现,多组分参与的氟烷基化反应取得了长足的进展,不仅可以经济有效地一步将氟烷基基团与其他官能团同步引入,而且可以将起始原料转化为多种含有生物活性或药物活性的化合物.按照三组分二氟烷基化反应、三组分三氟甲基化反应、三组分全氟烷基化反应、三组分单氟烷基化反应、三组分氟化反应以及四组分氟烷基化反应和总结7个部分,总结了多组分参与的氟烷基化反应在过去近十年时间里的发展进程,同时对该类反应进行了总结和展望.

Multi-component fluoroalkylation is a hot topic in organic fluorine chemistry.In the past few years,due to the development of new reagents and new methods,multi-component fluoroalkylation reactions have made great progress.It can not only introduce fluoroalkyl groups with other functional groups in one step economically and effectively,but also transform the starting materials into a variety of compounds with biological or pharmaceutical.The development of multi-component fluoroalkylation over the past decade is reviewed from seven parts:three-component difluoroalkylation reaction,three-component trifluoroalkylation reaction,three-component perfluoroalkylation reaction,three-component monofluoroalkylation reaction,three-component fluorination and four-component fluoroalkylation and conclusion.At the same time,this kind of reaction is summarized and prospected.