金鸡纳硅醚衍生物有机催化吲哚与靛红的不对称Friedel-Crafts反应

Enantioselective Friedel-Crafts Reaction of Indoles with Isatins Catalyzed by Cinchona Alkaloid Silyl Ether Derivative

金鸡纳硅醚衍生物用于有机催化不同吲哚和靛红的不对称Friedel-Crafts反应.筛选出最佳的催化剂体系,以78%~96%的产率和最高达99%的对映选择性获得了手性3-羟基-2-吲哚酮.拓宽了该反应的催化剂类型和底物范围.

A series of cinchona alkaloid silyl ether derivatives have been used to catalyze the enantioselective Friedel-Crafts reaction of indoles with isatins.The resulting 3-hydroxy-2-oxindoles were obtained in good yields(78%~96%)with high enantioselectivities(up to 99%ee).The catalyst type and the substrate scope were broadened in this methodology.