急性心肌梗死的分子成像研究进展

Research progress in the molecular imaging of acute myocardial infarction

心血管疾病尤其是冠状动脉粥样硬化性心脏病,在中国乃至世界范围内都是造成死亡的重要原因。冠状动脉粥样硬化的发生、斑块破裂和血栓形成,以及心肌梗死后心肌损伤和修复过程受到诸多复杂的细胞和分子信号网络的调控。当前临床使用的影像学手段可评估冠状动脉及心脏的解剖、灌注等,但无法准确体现病变的病理生理过程和病变的进展。近年来,分子成像技术使心血管疾病病理过程可视化和定量化成为可能,因而,对心血管疾病的精准诊断和预后判断具有重要的临床价值。文章综述了目前急性心肌梗死的分子成像研究最新进展。

Cardiovascular disease,especially coronary atherosclerotic heart disease,is the main cause of death in China and the world.The occurrence of coronary atherosclerosis,plaque rupture and thrombosis,as well as myocardial injury and repair process after myocardial infarction are regulated by many complex cellular and molecular signal networks.The current clinical imaging methods can assess the anatomy and perfusion of the coronary artery and heart,but they cannot accurately reflect the pathophysiological process and progression of the disease.In recent years,the development of molecular imaging technology has made the visualization and quantification of cardiovascular diseases pathological processes possible.Therefore,it has important clinical value for accurate diagnosis and prognostic judgement of cardiovascular diseases which assists clinical decision-making.This review aims to summarize the current molecular imaging research progress of acute myocardial infarction.