TM6SF2 rs58542926 T/C基因多态性与显著肝纤维化相关性的Meta分析

Association between TM6SF2 rs58542926 T/C Gene Polymorphism and Significant Liver Fibrosis:A Meta-analysis.

目的探讨TM6SF2 E167K基因多态性与显著肝纤维化的关系。方法计算机检索Central、Embase、Medline、PubMed数据库,检索时间范围为建库到2020年9月。按纳入、排除标准选择TM6SF2 E167K基因多态性与显著肝纤维化关系的病例对照研究。应用Stata 12.0软件对纳入的研究进行定量分析。结果共纳入7组病例对照研究,Meta分析结果显示,TM6SF2 rs58542926 T/C基因多态性与显著肝纤维化有明显的关联性(T vs C,OR=1.292,95%CI:1.035~1.611,P=0.023;TT vs CT+CC,OR=2.829,95%CI:1.101~7.267,P=0.031)。未发现明显的发表偏倚。结论Meta分析发现TM6SF2 E167K基因多态性可能与显著性肝纤维化易感性相关,T等位基因、TT基因型可能为显著性肝纤维化发病的易感因素。

Objective To further explore the association between Transmembrane 6 superfamily member 2(TM6SF2)rs58542926 T/C gene polymorphism and hepatic fibrosis.Methods In this study,the MEDLINE,PubMed,EMBASE,and CENTRAL databases were queried from inception to September,2020.According to inclusion and exclusion criteria,case-control studies assessing the relationship between TM6SF2 rs58542926 T/C gene polymorphism and significant liver fibrosis were selected.NOS scale was used to evaluate the included literature.Stata 12.0 software was used for data analysis.Results In this meta-analysis,a total of 7 articles were included.Statistical analysis showed that the TM6SF2 gene polymorphism was associated with significant liver fibrosis(T vs C,OR=1.292,95%CI:1.035-1.611,P=0.023;TT vs CT+CC,OR=2.829,95%CI:1.101-7.267,P=0.031).No significant publication bias was found after Egger′s test.Conclusion The present findings suggest that TM6SF2 E167K gene polymorphism may be associated with susceptibility to significant hepatic fibrosis.T allele and TT genotype may be the susceptibility factors of significant hepatic fibrosis.