年轻患者体外受精-胚胎移植后生化妊娠的相关因素分析

Analysis of Relevant Factors of Biochemical Pregnancy in Young Patients Undergoing in Vitro Fertilization-embryo Transfer.

目的探讨年轻患者行体外受精-胚胎移植(IVF-ET)治疗后发生生化妊娠的相关因素。方法回顾性分析了2019年1~12月在笔者医院首次行IVF-ET治疗,无自然流产史、无子宫解剖学异常的年轻患者,移植后生化妊娠的44例为研究组,同期IVF-ET后正常分娩的128例为对照组,比较两组一般情况和助孕指标,选择有统计学意义的指标行多因素Logistic回归分析,探讨年轻患者生化妊娠的相关影响因素。结果经多因素Logistic回归分析,发现年龄、宫外孕病史、获卵数、内膜厚度和移植优胚数是影响年轻患者生化妊娠的因素(P<0.05)。结论对于无自然流产史、无子宫解剖学异常的年轻患者,年龄增大、宫外孕病史可能是生化妊娠的危险因素;获卵数多、子宫内膜略厚和移植优质胚胎可能是妊娠活产的有利因素。

Objective To investigate the related factors of biochemical pregnancy in young patients undergoing in vitro fertilization-embryo transfer.Methods A retrospective analysis was performed on the young women,without spontaneous abortion and anatomical abnormality of uterus,who received IVF-ET in our hospital from January 2019 to December 2019.44 cases were enrolled for biochemical pregnancy group and 128 cases for delivery group.The general conditions and the assisted reproductive indicators were analyzed.Results Multiple Logistic regression analysis showed that age,history of ectopic pregnancy,number of retrieved oocytes,thickness of endometrium and number of high-quality embryos transplanted were the relevant factors of biochemical pregnancy in young patients(P<0.05).Conclusion The risk factors of biochemical pregnancy were older age and ectopic pregnancy in young patients without history of spontaneous abortion and anatomical abnormality of uterus.More retrieved oocytes,slightly thicker endometrium and high-quality embryos are protective factors for pregnancy.