丙种球蛋白治疗新生儿巨细胞病毒肺炎的临床疗效分析

Clinical Efficacy of Gamma Globulin in the Treatment of neonatal Cytomegalovirus Pneumonia

目的探讨对巨细胞病毒肺炎患儿使用丙种球蛋白治疗的临床效果。方法现对2017年1月至2020年1月山东滨州无棣县人民医院收治的60例巨细胞病毒肺炎患儿展开研究,依据双盲法将患儿分为人数均等常规组和研究组,各30例,两组患者均予以抗生素治疗,在明显患儿病情后,常规组患儿予以更昔洛韦进行治疗;研究组患儿则选用丙种球蛋白进行治疗,比较治疗总有效率、免疫功能、临床症状改善情况和不良反应发生情况之间的差异。结果研究组治疗总有效率(90.00%)明显高于常规组(76.67%),差异显著(P<0.05);常规组和研究组治疗前CD4^(+)、CD3^(+)以及CD4^(+)/CD8^(+)比值之间比较,无显著差异(P>0.05),治疗后,两组上述指标较本组治疗前相比均有显著提高,组内对比差异具有统计学意义(P<0.05),并且研究组治疗后上述免疫功能指标明显高于常规组(P<0.05);研究组肺炎症状消失的时间和住院时长均短于常规组,不良反应的总发生率(13.33%)也明显低于常规组(26.67%),差异显著(P<0.05)。结论对巨细胞肺炎患儿使用丙种球蛋白治疗可以有效缩短治疗和住院时长,促进患儿免疫功能的恢复,减少不良反应的发生,提高患儿的治疗效果,保障患儿的治疗安全,临床应用效果显著。

Objective To investigate the clinical effect of gamma globulin on children with cytomegalovirus pneumonia.Methods From January 2017 to January 2020,60 children with pneumonia in Wudi county people's Hospital of Binzhou,Shandong province,were divided into two groups according to the double-blind method,30 cases in each group,patients in both groups were treated with antibiotics,and children in the conventional group were treated with ganciclovir after an obvious illness,while children in the study group were treated with gamma globulin,the total effective rate,immune function,improvement of clinical symptoms and adverse reactions were compared.Results The total effective rate(90.00%)of the study group was significantly higher than that of the routine group(76.67%)(P<0.05),and there was no significant difference between the routine group and the study group in the ratio of CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)before treatment(P>0.05),the above-mentioned indexes in the two groups were significantly higher than those in the control group(P<0.05),and the abovementioned indexes in the study group were significantly higher than those in the control group(P<0.05),.The duration of pneumonia symptom disappearance and hospitalization in the study group were shorter than that in the routine group,and the total incidence of adverse reactions(13.33%)was significantly lower than that in the routine group(26.67%),the difference was significant(P<0.05).Conclusion Immunoglobulin therapy for children with giant cell pneumonia can effectively shorten the length of treatment and hospitalization,promote the recovery of immune function,reduce the occurrence of adverse reactions,and improve the therapeutic effect of children with giant cell pneumonia,to ensure the treatment of children with safety,the clinical application effect is remarkable.