不同剂量伊曲康唑制剂对犬血常规及肝肾功能的影响

Effects of Different Doses of Itraconazole Fumulation on Blood Routine and Liver and Kidney Functions in Dogs

旨在评价不同剂量伊曲康唑-环糊精制剂通过皮下注射途径对健康比格犬肝肾功能及血常规的影响。选用体重±10 kg的健康纯种比格犬32只,按试验要求随机分为4组,每组8只,建立稳定的生活制度。分别按照0.25 mg/kg、0.75 mg/kg和1.25 mg/kg剂量,皮下注射伊曲康唑制剂,3日1次,连续7次,对照组注射生理盐水。于试验过程中第0、5、10、15、19天采集相关样品,对犬临床表现、血常规指标、血液生化指标、尿常规指标及肝肾功能进行全面的评价。结果表明,给药组与对照组相比,除白细胞相关指标外,其余指标都在正常范围内。给药组在试验过程中均出现白细胞升高现象,但在试验结束后5 d内均恢复正常。因此,伊曲康唑-环糊精制剂作为犬皮下注射剂型,具有良好的安全性和耐受性,操作方便,动物依从性好,适合兽医临床应用。

The purpose of this study was to evaluate the effects of different doses of itraconazole-cyclodextrin formulation on the liver and kidney functions and blood routine of healthy Beagle dogs by subcutaneous injection.Thirty-two healthy purebred Beagle dogs weighing±10 kg were selected and randomly divided into 4 groups according to the test requirements,with 8 in each group,a stable living system was established.At a dose of 0.25,0.75 and 1.25 mg/kg,the itraconazole formulation was injected subcutaneously once every 3 days for 7 consecutive times,and the control group was injected with saline.Relevant samples were collected on the 0,5,10,15,and 19 days of the experiment.The dog's clinical performance,blood routine examination,blood biochemical examination,urine routine examination were systematically evaluation.The results showed that,compared with the control group,except for leukocyte-related indicators,the other indicators were not significantly abnormal and were within the normal range.In the three administration groups,leukocytes increased during the test,but returned to normal within five days after the end of the experiment.Therefore,itraconazole-cyclodextrin formulation,as a subcutaneous injection for dogs,has good safety and tolerance,easy and fast operation,good animal compliance,and is suitable for veterinary clinical applications.