漱口方预防激素雾化吸入后口腔真菌感染的临床观察

Clinical observation of Shukoufang in preventing oral fungal infection after inhaled corticostroids

目的探究漱口方预防激素雾化吸入后口腔真菌感染的临床效果。方法对2019年2月—2020年2月在日照市中心医院接受布地奈德混悬液等激素雾化治疗的患者进行观察,按照随机数字表将选取的72例患者随机分入对照组与观察组,各36例。其中对照组在激素雾化治疗后清水漱口,观察组患者在激素雾化治疗后漱口方漱口,对比两组患者的真菌感染预防效果。结果激素雾化治疗7 d后,观察组咽拭真菌培养阳性率低于对照组,P<0.05,有统计学意义。两组患者均以白假丝酵母菌感染为主,观察组达到66.67%,对照组为64.29%;其余分布较少的有克柔氏念珠菌、光滑念珠菌。结论漱口方在预防激素雾化吸入后口腔真菌感染中具有较理想的应用效果,可显著降低真菌感染的风险,继而保障患者雾化吸入治疗的持续开展和原发疾病治疗的疗效。

Objective:To explore the clinical effect of Shukoufang on the prevention of oral fungal infection after inhaled corticosteroids.Methods:The patients who received budesonide suspension and other hormone atomization treatment in Rizhao General Hospital were observed from February 2019 to February 2020.According to the random number table,72 patients were randomly divided into the control group and the observation group,with 36 cases in each.Among them,the control group rinsed their mouth with water after the hormone atomization treatment,and the observation group with gargle formula after the hormone atomization treatment.Results:The positive rate of pharyngeal swab fungus culture in the observation group was lower than that in the control group(P<0.05).The infection rate of Candida albicans was 66.67%in the observation group and 64.29%in the control group.Conclusion:Shukoufang has an ideal application effect in the prevention of oral fungal infection after hormone atomization inhalation,which can significantly reduce the risk of fungal infection,and then guarantee the continuous development of patients'atomization inhalation treatment and the efficacy of primary disease treatment.