脑缺血再灌注的治疗对脑梗死患者认知功能的影响

Impacts of cerebral ischemia reperfusion therapy on cognitive function of patients with cerebral infarction

目的探讨脑缺血再灌注的治疗对脑梗死患者认知功能的影响。方法选择2019年7—12月在牡丹江医学院附属第二医院(我院)诊断并行再灌注治疗的急性脑梗死患者30例为观察组,选择同期在我院诊断未行溶栓治疗的急性脑梗死患者30例为对照组。比较两组治疗前后NIHSS评分、MMSE评分以及MoCA评分。结果治疗后3个月,两组NIHSS评分均显著低于治疗前,差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分显著低于对照组,差异有统计学意义(P<0.05)。治疗后1、6个月,两组MMSE评分显著高于治疗前,差异有统计学意义(P<0.05);治疗后1、6个月,观察组MMSE评分显著高于对照组,差异有统计学意义(P<0.05)。治疗后1、6个月,两组MoCA评分显著高于治疗前,差异有统计学意义(P<0.05);治疗后1、6个月,观察组MoCA评分显著高于对照组,差异有统计学意义(P<0.05)。结论再灌注治疗可显著改善急性脑梗死患者的认知功能。

Objective To investigate the impacts of cerebral ischemia reperfusion therapy on cognitive function of patients with cerebral infarction.Methods Patients with acute cerebral infarction diagnosed in the Second Affiliated Hospital of Mudanjiang Medical University(our hospital)and treated with reperfusion from July to December 2019 were selected as the observation group(n=30),and other patients with acute cerebral infarction diagnosed in our hospital without thrombolytic therapy during the same period were selected as the control group(n=30).NIHSS score,MMSE score and MoCA score were compared between the two groups before and after treatment.Results 3 months after treatment,the NIHSS scores of the two groups were both significantly lower than those before treatment(P<0.05).After treatment,the NIHSS score of the observation group was significantly lower than that of the control group(P<0.05).1 month and 6 months after treatment,the MMSE scores of the two groups were significantly higher than those before treatment(P<0.05).1 month and 6 months after treatment,the MMSE average score of the observation group was significantly higher than that of the control group(P<0.05).1 month and 6 months after treatment,the MoCA scores of the two groups were significantly higher than those before treatmen(P<0.05).1 month and 6 months after treatment,the MoCA average score of the observation group was significantly higher than that of the control group,with statistically significant difference(P<0.05).Conclusion Reperfusion therapy can significantly improve the cognitive function of patients with acute cerebral infarction.