功能性消化不良患者内脏高敏感性与血清Ghrelin水平的相关性研究

Research on the correlation between visceral hypersensitivity and serum Ghrelin level in patients with functional dyspepsia

目的探究功能性消化不良患者内脏高敏感性与血清Ghrelin水平的相关性。方法选择2018年1—12月在福建省老年医院就诊的功能性消化不良患者80例设为FD组,根据疾病亚型分为PDS亚组(n=40)和EPS亚组(n=40),另选同期健康体检者40例设为正常对照组,均开展37℃饮水负荷试验测量胃感知阈值及胃不适阈值,并进行血清Ghrelin水平检测,比较各组的检测结果。同时,采用Pearson相关系数分析胃感知阈值、胃不适阈值与血清Ghrelin水平的相关性。结果FD组的胃感知阈值、胃不适阈值、血清Ghrelin水平显著低于正常对照组(P<0.05),且EPS亚组患者的上述各项指标检测值均较PDS亚组明显减少(P<0.05)。经Pearson相关性分析发现,EPS患者的胃感知阈值、胃不适阈值与血Ghrelin水平均呈正相关(P<0.05)。而PDS患者的胃感知阈值与血Ghrelin水平均无相关性(P>0.05)。结论功能性消化不良尤其是EPS的病理生理机制为内脏高敏感性,而血清Ghrelin水平与内脏高敏感性呈正相关,故通过对其检测能够在一定程度指导疾病分型及治疗,提高诊疗效率。

Objective To investigate the correlation between visceral hypersensitivity and serum Ghrelin level in patients with functional dyspepsia.Methods A total of 80 patients with functional dyspepsia admitted to Fujian Geriatric Hospital from January to December 2018 were selected as the FD group(n=80),which were divided into the PDS subgroup(n=40)and the EPS subgroup(n=40)according to disease subtypes.Another 40 healthy patients who have undergone physical examination in the same period were selected as the normal control group(n=40).The gastric perception threshold and gastric discomfort threshold were measured by drinking water load test at 37℃,and the serum Ghrelin level was detected.The detection results of each group were compared.Meanwhile,Pearson correlation coefficient was used to analyze the correlation between gastric perception threshold,gastric discomfort threshold and serum Ghrelin level.Results The gastric perception threshold,gastric discomfort threshold and serum Ghrelin level in the FD group were significantly lower than those in the normal control group(P<0.05).The above detection values of these indexes in the EPS subgroup were all significantly lower than those in the PDS subgroup(P<0.05).Pearson correlation analysis showed that gastric perception threshold,gastric discomfort threshold and serum Ghrelin level in patients of the PDS subgroup were positively correlated(P<0.05).However,there was no correlation between gastric perception threshold and serum Ghrelin level in patients of the PDS subgroup(P>0.05).Conclusion The pathophysiological mechanism of functional dyspepsia,especially EPS,is visceral hypersensitivity,and the serum Ghrelin level is positively correlated with visceral hypersensitivity.Therefore,the detection of Ghrelin can guide the classification and treatment of diseases to a certain extent and improve the efficiency of diagnosis and treatment.