近红外光谱对早产儿脑组织氧饱和度监测的临床应用

Advances in clinical application of near-infrared spectroscopy in monitoring oxygen saturation in brain tissue of premature infants

与经皮血氧饱和度(percutaneous oxygen saturation,SpO2)相比,脑组织氧饱和度(cerebral regional tissue oxygen saturation,CrSO2)反映的是脑组织的混合氧饱和度,其变化与新生儿生后脑组织的新陈代谢密切相关。近红外光谱技术(near-infrared spectroscopy,NIRS)是一项无创的连续监测技术,且可提供脑组织血流变化及损伤的相关信息,在部分新生儿重症监护病房中NIRS已作为一项常规监测手段。虽然现阶段的研究尚未明确提出NIRS在新生儿脑损伤中的诊断意义,但研究发现检测CrSO2的变化并对异常值进行相应干预可减少早产儿脑损伤的发生率。CrSO2与脑损伤的关系以及影响CrSO2的因素是目前的研究热点。该文综述了影响CrSO2变化的因素以及维持其稳定的临床干预措施。

Compared with percutaneous oxygen saturation(SpO2),cerebral regional tissue oxygen saturation(CrSO2)reflects the mixed oxygen saturation of brain tissue,and its change is closely correlated with the metabolism of brain tissue after birth.Near-infrared spectroscopy(NIRS)is a non-invasive continuous monitoring technology,which can provide information about changes in blood flow and damage of brain tissue.For now,NIRS has been used as a routine monitoring method in some neonatal intensive care units.Although the current research has not clearly proposed the diagnostic significance of NIRS in neonatal brain injury,current studies have found that detecting changes in CrSO2 and corresponding interventions in abnormal values can reduce the incidence of brain injury in premature infants.The relationship between CrSO2 and brain injury and the factors affecting CrSO2 are still the current research hotspots.This article reviews the factors affecting the changes of CrSO2 and clinical interventions to maintain its stability.