罗红霉素、醋酸泼尼松和多索茶碱联合治疗间质性肺炎的临床效果观察

Clinical effect of roxithromycin,prednisone acetate and doxofylline in the treatment of interstitial pneumonia

目的:探讨罗红霉素、醋酸泼尼松和多索茶碱联合治疗间质性肺炎的临床效果。方法:2019年1月-2020年6月收治间质性肺炎患者94例,随机分为两组,各47例。对照组单用罗红霉素治疗,观察组在罗红霉素基础上使用醋酸泼尼松和多索茶碱联合治疗,比较两组临床疗效、肺功能指标水平、MMRC评分和ADL评分变化。结果:观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组治疗后MVVL、PEFL、DLCO、FEV1/FVC水平均明显高于对照组,差异有统计学意义(P<0.05);观察组治疗后MMRC评分明显低于对照组,ADL评分明显高于对照组,差异有统计学意义(P<0.05)。结论:罗红霉素、醋酸泼尼松和多索茶碱联合治疗间质性肺炎的临床效果显著,能有效抑制炎症,改善肺功能,提升患者生活质量。

Objective:To explore the clinical effect of roxithromycin,prednisone acetate and doxofylline in the treatment of interstitial pneumonia.Methods:From January 2019 to June 2020,94 patients with interstitial pneumonia were selected and randomly divided into two groups with 47 cases in each group.The control group was treated with roxithromycin alone.The observation group was treated with prednisone acetate combined with doxofylline on the basis of roxithromycin.We compared the clinical efficacy,lung function index level,MMRC score and ADL score between the two groups.Results:The effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).In the observation group,after treatment,MVVL,PEFL,DLCO,FEV1/FVC levels were significantly higher than those in the control group,the difference was statistically significant(P<0.05).In the observation group,after treatment,MMRC score was significantly lower than that of the control group,while ADL score was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:The clinical effect of roxithromycin,prednisone acetate and doxofylline in the treatment of interstitial pneumonia is significant,it can effectively inhibit inflammation,improve lung function and improve the quality of life of patients.