海藻多糖对子宫内膜症大鼠炎症反应和氧化应激的影响

Effects of alga polysaccharide on inflammatory response and oxidative stress in rats with endometriosis

目的探讨海藻多糖对模型大鼠子宫内膜异位症(EMS)的治疗效果及对其血清中促卵泡生成激素(FSH)、促黄体生成素(LH)、丙二醛(MDA)和白介素-6(IL-6)水平的影响。方法分为对照组、模型组和3个不同剂量的海藻多糖组共5组。造模4周后开始给药,给药2周后,观察不同药物剂量的海藻多糖对EMS大鼠模型病理学的改变和血清中FSH、LH、MDA和IL-6含量变化。结果海藻多糖对EMS大鼠疗效具有剂量依赖性,海藻多糖组腺体的萎缩和减少程度以及血清中FSH、LH、MDA和IL-6的含量均低于模型组。结论海藻多糖能够抑制异位内膜组织的增生、加快炎症消退,其作用机制可能是能够降低血清中FSH、LH、MDA和IL-6含量,从而达到治疗EMS的效果。

Objective To investigate the therapeutic effect of alga polysaccharide on endometriosis(EMS)and its effects on serum levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),malondialdehyde(MDA)and interleukin-6(IL-6).Methods The rats were divided into five groups:the control group,the model group and three alga polysaccharide groups with different doses.Four weeks later,the rats were treated with alga polysaccharide at different doses.The pathological changes and serum levels of FSH,LH,MDA and IL-6 in rats with endometriosis were observed after 2 weeks of administration.Results The therapeutic effect of alga polysaccharide on endometriosis in rats was dose-dependent.The degree of atrophy and decrease of the glands and the serum levels of FSH,LH,MDA and IL-6 significantly decreased in alga polysaccharide groups compared with the model group.Conclusion Alga polysaccharide achieves the therapeutic effect of EMS in rats,and the underlying mechanisms may be through significantly inhibiting the proliferation of ectopic endometrium,accelerating the regression of inflammation,and reducing the levels of FSH,LH,MDA and IL-6 in serum.