乳腺癌全数字化X线摄影影像特征与分子分型的相关性

Correlation between mammographic characteristics and molecular subtypes of breast cancer

目的分析乳腺癌全数字化X线摄影直接征象及肿物特征与免疫组化不同分子分型的相关性,验证术前根据X线摄影检查预测分子分型的可行性。方法对某院139例乳腺癌病例的X线摄影影像特征及其分子分型进行统计学分析。结果在所有乳腺癌X线影像中,肿块所占比例最高,而在免疫组化分子分型中,Luminal B型所占比例最高;乳腺癌影像特征和不同分子分型之间具有统计学意义(P<0.01),乳腺癌的肿块边缘特征以及肿块有无伴有钙化与分子分型呈现明显的相关性(P<0.01);三阴性型和Luminal A型乳腺癌大多数显示为肿块型,钙化罕见于三阴性型,边缘毛刺较多见于Luminal A型;Her-2过表达型的影像表现不尽相同。结论通过全数字化X线摄影检查乳腺癌有助于鉴别其分子分型,在一定程度上可以指导临床确定治疗方案,并进行预后判断。

Objective To verify the feasibility of predicting molecular subtypes based on mammography before surgery by analyzing the direct signs of breast cancer and the tumor characteristics and different molecular subtypes in immunohistochemistry.Methods The X-ray features and molecular typing of 139 cases of breast cancer in our hospital were analyzed statistically.Results Among all the mammographic characteristics of breast cancer,tumor was the most common type,and Luminal B was the most common molecular subtype.The direct signs of breast cancer were statistically significant with different molecular typing,P<0.01,and there was a significant correlation between the edge characteristics of breast cancer mass and whether there was calcification in the mass and molecular typing,P<0.01.Most breast cancers of the triple negative type and Luminal A type showed mass type,calcification was rare in the triple negative type,and marginal burrs were more common in the Luminal A type.Images with her-2 overexpression were not the same.Conclusion Mammography of breast cancer is helpful to differentiate its molecular subtypes,and to a certain extent can guide the clinical determination of treatment plan and prognosis judgment.