根除幽门螺杆菌疗法治疗难治性免疫性血小板减少性紫癜的研究

Study on Helicobacter pylori eradication therapy for the treatment of refractory immune thrombocytopenic purpura

目的研究根除幽门螺杆菌(Hp)疗法治疗难治性免疫性血小板减少性紫癜(RITP)的效果。方法35例RITP患者作为治疗观察对象,先对患者进行C尿素呼吸试验(C-UBT)诊断和抗血小板抗体IgG(PA-IgG)检测,根据结果等信息对患者进行根除Hp治疗。观察并比较治疗前和治疗后1、2、3个月患者血小板计数(PLT)和PA-IgG水平。结果治疗后1、2、3个月,患者PLT水平分别为(31.50±8.45)×10^(9)/L、(38.70±7.39)×10^(9)/L、(46.91±5.41)×10^(9)/L,明显高于治疗前的(23.14±5.67)×10^(9)/L,PAIgG水平分别为(363.74±102.31)μg/10^(7)血小板、(273.64±94.26)μg/10^(7)血小板、(223.20±75.21)μg/10^(7)血小板,明显低于治疗前的(422.30±100.24)μg/10^(7)血小板,差异均具有统计学意义(P<0.05)。结论对RITP患者采用根除Hp治疗,可加快患者PLT和PA-IgG水平恢复,该治疗方式应用效果理想,值得推广使用。

Objective To study the effect of Helicobacter pylori(Hp)eradication therapy for the treatment of refractory immune thrombocytopenic purpura(RITP).Methods 35 RITP patients as observation subjects all were first diagnosed with C-urea breath test(C-UBT)and platelet associated IgG(PA-IgG)detection,and based on the results and other information,the patients received Hp eradication.The levels of platelet count(PLT)and PA IgG were observed and compared before treatment and 1,2,3 months after treatment.Results 1,2,3 months after treatment,the PLT of patients were(31.50±8.45)×10^(9)/L platelet,(38.70±7.39)×10^(9)/L platelet and(46.91±5.41)×10^(9)/L,which were obviously higher than(23.14±5.67)×10^(9)/L before treatment,and the PAIgG were(363.74±102.31)μg/10^(7) platelet,(273.64±94.26)μg/10^(7) plateletand(223.20±75.21)μg/10^(7) platelet,which were obviously lower than(422.30±100.24)μg/10^(7) before treatment.All the difference was statistically significant(P<0.05).Conclusion Hp eradication therapy for RITP patients can speed up the recovery of PLT and PA-IgG levels in patients.This treatment has ideal effects and is worthy of popularization and application.