多重药理学:药物发现的新机遇

Polypharmacology:A new opportunity for drug discovery

近年来,越来越多的证据表明,药物分子通常与多个靶点相互作用,将研究这种现象的学科称作多重药理学,这将会改变传统的药物发现和设计策略,开辟设计更有效药物的新途径。具有多重药理学作用的药物能够同时作用于疾病中的多个治疗靶点,如果对各靶点产生协同作用,使其总效应大于各单效应之和,就能达到最佳的治疗效果。本文简要介绍了多重药理学的概念、药物设计方法以及未来应用前景。

In recent years,more and more evidences show that drug molecules usually interact with multiple targets.Polypharmacology focuses on such phenomena,and will open up a new way to design more effective drugs,thus changing the traditional drug discovery and design strategies.Drugs with polypharmacological effects achieve better therapeutic effect via acting on multiple targets at the same time.They may have synergistic effect on each target,and the total effect is greater than the sum of single effect.This paper briefly introduced the concept of polypharmacology,drug design methods and application prospects.