卡前列素氨丁三醇联合垂体后叶素对胎盘早剥产后出血患者止血效果及分娩结局的影响

Effect of Carboprost Aminobutanol Combined with Pituitrin on hemostatic effect and Delivery Outcome in Patients with Postpartum Hemorrhage After Placental Abruption

目的探究卡前列素氨丁三醇联合垂体后叶素对胎盘早剥产后出血患者止血效果及分娩结局的影响。方法选择2017年9月至2020年6月我院收治的胎盘早剥出血患者96例,按随机数字表法分为两组,各48例。对照组给予卡前列素氨丁三醇+缩宫素治疗,观察组在此基础上给予垂体后叶素治疗。比较两组止血时间、产后出血量、凝血功能及不良事件发生率。结果观察组止血时间(20.63±4.35)min,短于对照组,产后0.5、2、24 h出血量分别为(273.54±18.21)ml、(288.53±20.67)ml、(296.04±19.25)ml,均少于对照组,差异有统计学意义(P<0.05);治疗前,两组凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fib)比较,差异无统计学意义(P>0.05);治疗后,观察组TT(19.62±4.33)s、APTT(41.29±8.06)s、Fib(3.22±0.64)g/L,优于对照组,差异有统计学意义(P<0.05);观察组不良事件发生率(12.50%)低于对照组(31.25%),差异有统计学意义(P<0.05)。结论卡前列素氨丁三醇联合垂体后叶素对胎盘早剥产后出血患者止血效果显著,可改善产妇凝血功能,并减少不良事件的发生。

Objective To investigate the effect of caprost aminobutanol combined with pituitrin on hemostasis and delivery outcome in patients with postpartum hemorrhage after placental abruption.Methods 96 cases of placental abruption bleeding from September 2017 to June 2020,Divided into two groups according to the random number table method,48 cases each.The control group was treated with carboprost aminobutanol oxytocin,The observation group was treated with pituitrin on this basis.The hemostatic time,postpartum hemorrhage,coagulation function and incidence of adverse events were compared between the two groups.Results Hemostatic time(20.63±4.35)min,in observation group Short,Postpartum 0.5 h、2 h、24 h bleeding were(273.54±18.21)ml、(288.53±20.67)ml、(296.04±19.25)ml,and Less than the control group,difference was statistically significant(P<0.05);Before treatment,Two groups of thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(Fib)comparison,(b)The difference was not statistically significant(P>0.05);After treatment,Observation group TT(19.62±4.33)s、APTT 41.29 TT(19.62±8.06)s、Fib(3.22 TT(19.62±0.64)g/L,)Better than the control group,difference was statistically significant(P<0.05);The incidence of adverse events in the observation group(12.50%)was lower than that in the control group(31.25%),difference was statistically significant(P<0.05).Conclusion Preprostatin aminobutanol combined with pituitrin has remarkable hemostatic effect on patients with postpartum hemorrhage after placental abruption,which can improve coagulation function and reduce adverse events.