肠道菌群与注意缺陷多动障碍的研究进展

Advances in Research on Relationship between Attention Deficit Hyperactivity Disorder and Intestinal Flora

肠道菌群是目前生物学领域的研究热点,近年其与人类中枢神经系统疾病之间的关系受到广泛关注。注意缺陷多动障碍(ADHD)是儿童常见的一种神经精神类疾病,目前病因及发病机制尚不明确,可能由遗传因素、环境因素及其相互作用导致。ADHD患者往往存在肠道菌群异常,肠道菌群可通过神经、免疫和调节神经递质参与调控ADHD的发生、发展及治疗。因此,了解肠道菌群、肠-脑轴与ADHD之间的相互作用能为ADHD的早期干预和治疗提供新的靶点。

Intestinal flora is currently the research hotspot in the field of biology.In recent years,the relationship of intestinal flora and human central nervous system diseases has received extensive attention.Attention deficit hyperactivity disorder(ADHD)is a common neuropsychiatric disease in children,the etiology and pathogenesis of which are not clear so far.It may be caused by genetic factors,environmental factors and their interaction.ADHD patients often have abnormal intestinal flora.Intestinal flora can participate in regulating the occurrence,development and treatment of ADHD through nervous system,immunity and regulating neurotransmitters.Therefore,understanding the interaction between intestinal flora,gut-brain axis and ADHD can provide new targets for the early intervention and treatment of ADHD.