长链非编码RNA在心力衰竭中的作用及临床意义

Role and clinical significance of long non-coding RNA in heart failure

长链非编码RNA(lncRNA)曾被认为是基因组转录的“噪音”,不具有生物学功能。近年来,越来越多的证据表明,lncRNA在不同发育阶段或疾病状态中动态表达,并且在基因表达和翻译的诸多环节中都发挥调节作用。作为一种调节因子,lncRNA已被证实参与心脏生长发育的基因调控,同时参与心力衰竭的多个病理变化,主要包括心肌肥大、纤维化和血管新生等。因此,lncRNA被认为是控制心脏生理和病理复杂调节网络的核心枢纽,有望成为心力衰竭的治疗靶标。本文综述心力衰竭中lncRNA的作用和机制,并评估了lncRNA在临床诊治中的前景。

Long non-coding RNA(lncRNA)was once considered to be the“noise”of genome transcription without biological function.In recent years,increasing evidence shows that lncRNA is dynamically expressed at different developmental stages or disease statuses and plays a regulatory role in gene expression and translation.In particular,the effectiveness of lncRNA has been proven in gene regulation of cardiac development.It also participates in multiple pathological changes of heart failure such as cardiac hypertrophy,fibrosis,angiogenesis,etc.Therefore,lncRNA is considered to be the core hub of complex regulatory networks controlling cardiac physiology and pathology,and is expected to become a therapeutic target for heart failure.This article reviews the role and mechanism of lncRNA in heart failure,and evaluates its prospects in the future clinical diagnosis and treatment.