氮杂环卡宾催化下合成(4-硝基)苯甲酸苄酯及其衍生物

Synthesis of Benzyl 4-Nitrobenzoate Catalyzed by Nitrogen Heterocyclic Carbene

目的研究(4-硝基)苯甲酸苄酯的合成。方法在氮杂环卡宾条件下,以四氢呋喃为溶剂,N,N-二异丙基乙胺为碱,以苄溴与对硝基苯甲醛为原料反应制备(4-硝基)苯甲酸苄酯。结果目标化合物总收率为97%,结构经^(1)H NMR和^(13)C NMR分析确认。结论提供一条目标化合物新合成方法,探索了酸碱条件、反应温度等对目标化合物的影响,利用优化条件合成了几个衍生物。

Objective To explore the synthesis of 4-nitrobenzyl benzoate.Methods Benzyl benzoate(4-nitro)was prepared from benzyl bromide and p-nitrobenzaldehyde under the condition of N-Heterocyclic Carbene,using tetrahydrofuran as solvent and N,N-diisopropyl ethylamine as base.Results The total yield of the target compound was 97%,and the structure was confirmed by ^(1)H NMR and ^(13)C NMR.Conclusion A new synthetic method of target compounds was provided.The effects of acid-base conditions and reaction temperature on the target compounds were explored.Several derivatives were synthesized under the optimized conditions.