抗精神病药所致代谢异常的机制研究进展

Research progress on the mechanisms of antipsychotic-induced metabolic disturbances

代谢综合征已成为精神分裂症患者的主要健康问题,抗精神病药可导致代谢异常,并且不同药物和人群的表现存在差异。通过动物模型研究显示抗精神病药可致代谢异常,但转化效力易受研究设计的影响。抗精神病药引起的能量失衡和食欲调节激素水平改变可能在代谢异常中发挥重要的作用。本文中介绍了抗精神病药所致体重增加、血糖紊乱以及动物模型研究和食欲摄食调节机制的相关研究进展。

Metabolic syndrome has become a major health issue in patients with schizophrenia.Antipsychotic medications can induce metabolic disturbances and the features of these metabolic disturbances vary across different drugs and populations.Metabolic side effects of antipsychotic drugs have been duplicated in animal models,in which the translational validity can be influenced by experimental designs.The energy imbalance and change of appetite-regulating hormones may play important roles in antipsychotic-induced metabolic disturbances.This review introduces antipsychotic-induced weight gain and glucose dysregulation and then demonstrates the research progress on animal models and regulating mechanisms of appetite and feeding behaviors and the related problems remained to be explored.