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灯银脑通胶囊联合银杏达莫注射液治疗急性脑梗死的临床研究 被引量:10

Clinical study on Dengyin Naotong Capsules combined with Ginkgo Leaf Extract and Dipyridamole Injection in treatment of acute cerebral infarction
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摘要 目的探讨灯银脑通胶囊联合银杏达莫注射液治疗急性脑梗死的临床疗效。方法选取2016年1月—2019年12月平煤神马医疗集团总医院收治的180例急性脑梗死患者,随机分为对照组和治疗组,每组各90例。对照组静脉滴注银杏达莫注射液,25 mL加至500 mL生理盐水中,2次/d。治疗组在对照组治疗的基础上口服灯银脑通胶囊,2粒/次,3次/d。两组均连续治疗14 d。观察两组的临床疗效,比较两组中医证候积分、神经功能缺损程度评分(NDS)、血清学指标的变化情况。结果治疗后,治疗组总有效率为97.78%,显著高于对照组的74.44%(P<0.05)。治疗后,两组中医证候积分、NDS评分均明显比治疗前低(P<0.05);同时治疗组治疗后中医证候积分、NDS评分均明显比对照组低(P<0.05)。两组治疗后血清总胆固醇(TC)、低密度脂蛋白(LDL-C)、脂蛋白相关磷脂酶A2(Lp-PLA2)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均明显比治疗前低(P<0.05),同时治疗组治疗后这些指标水平均明显比对照组低(P<0.05)。结论灯银脑通胶囊联合银杏达莫注射液治疗急性脑梗死的临床疗效显著,能够明显减轻临床症状,改善神经功能缺损,调节血脂水平,抑制炎症反应,具有一定的临床推广应用价值。 Objective To investigate the clinical efficacy of Dengyin Naotong Capsules combined with Ginkgo Leaf Extract and Dipyridamole Injection in treatment of acute cerebral infarction.Methods A total of 180 patients with acute cerebral infarction admitted to General Hospital of Pingmei Shenma Medical Group from January 2016 to December 2019 were selected and randomly divided into control group and treatment group,with 90 patients in each group.Patients in the control group were iv administered with Ginkgo Leaf Extract and Dipyridamole Injection,25 mL added to 500 mL normal saline,twice daily.Patients in the treatment group were po administered with Dengyin Naotong Capsules on the basis of the control group,2 grains/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacy was evaluated,and the changes of TCM syndrome score,neurological deficit score(NDS)and serological indexes were compared between the two groups.Results After treatment,the total effective rate of the treatment group was 97.78%,which was significantly higher than that of the control group(74.44%,P<0.05).After treatment,TCM syndrome score and NDS score in both groups were significantly lower than those before treatment(P<0.05).After treatment,the TCM syndrome score and NDS score in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,serum levels of TC,LDL-C,Lp-PLA2,hs-CRP,TNF-α,and IL-6 in two groups were significantly lower than before treatment(P<0.05).After treatment,the levels of these indexes in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Dengyin Naotong Capsules combined with Ginkgo Leaf Extract and Dipyridamole Injection has significant clinical efficacy in treatment of acute cerebral infarction,and can significantly reduce clinical symptoms,also can improve neurological function defects,regulate blood lipid levels and inhibit inflammatory response,which has certain clinical application value.
作者 柳洲 朱志勇 牛永义 张宏伟 LIU Zhou;ZHU Zhi-yong;NIU Yong-yi;ZHANG Hong-wei(Department of Pharmacy,General Hospital of Pingmei Shenma Medical Group,Pingdingshan 467000,China;Department of Cardiovascular Medicine,General Hospital of Pingmei Shenina Medical Group,Pingdingshan 467000,China;Department of Traditional Chinese Medicine,General Hospital of Pingmei Shenma Medical Group,Pingdingshan 467000,China;Department of Neurolog,General Hospital of Pingmei Shenma Medical Group,Pingdingshan 467000,China)
出处 《现代药物与临床》 CAS 2021年第3期461-465,共5页 Drugs & Clinic
基金 河南省医学科技攻关计划项目(2018020215)。
关键词 灯银脑通胶囊 银杏达莫注射液 急性脑梗死 中医证候积分 神经功能缺损程度评分 脂蛋白相关磷脂酶A2 超敏C反应蛋白 Dengyin Naotong Capsules Ginkgo Leaf Extract and Dipyridamole Injection acute cerebral infarction TCM syndrome score neurological deficit score(NDS) Lp-PLA2 hs-CRP
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