黄藤素胶囊联合左氧氟沙星治疗子宫内膜炎的临床研究

Clinical study on Huangtengsu Capsules combined with levofloxacin in treatment of endometritis

目的探讨黄藤素胶囊联合左氧氟沙星片治疗子宫内膜炎的临床疗效。方法选取2019年3月—2020年10月河南中医药大学第三附属医院收治的94例子宫内膜炎患者,按照随机数字表法将所有患者分为对照组和治疗组,每组各47例。对照组口服左氧氟沙星片,0.5 g/次,1次/d,7 d为1个疗程,连续治疗3个疗程。治疗组在对照组基础上口服黄藤素胶囊,2粒/次,2次/d,连续治疗3周。观察两组的治愈率,对患者的下腹坠痛程度采用视觉模拟评分法(VAS)进行评估,检测两组治疗前后血清中基质金属蛋白酶-9(MMP-9)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)水平。结果治疗后,治疗组的治愈率(87.23%)明显高于对照组(70.21%),差异有统计学意义(P<0.05)。治疗后,治疗组患者盆腔疼痛、白带增多的消失时间比对照组短,差异有统计学意义(P<0.05)。治疗后,两组患者VAS评分均明显降低(P<0.05),以治疗组降低的更明显(P<0.05)。治疗后,两组的MMP-9、IL-6水平明显降低,IL-4水平明显升高(P<0.05);治疗后,治疗组的MMP-9、IL-6水平低于对照组,IL-4水平高于对照组,差异有统计学意义(P<0.05)。结论黄藤素胶囊联合左氧氟沙星片可提高子宫内膜炎的临床疗效,改善主要症状,调节炎症反应,且安全性良好。

Objective To investigate the clinical effect of Huangtengsu Capsules combined with Levofloxacin Tablets in treatment of endometritis.Methods Patients(94 cases)with endometritis in Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from March 2019 to October 2020 were randomly divided into control and treatment groups,and each group had 47 cases.Patients in the control group were po administered with Levofloxacin Tablets,0.5 g/time,once daily.A course of treatment had 7 d,and they had continuous treatment for 3 courses.Patients in the treatment group were po administered with Huangtengsu Capsules on the basis of the control group,2 grains/time,twice daily,and had continuous treatment for 3 weeks.After treatment,the clinical efficacies were evaluated,and the cure rate of two groups was observed,the degree of lower abdominal pain was evaluated by visual analogue scale(VAS),and the serum levels of MMP-9,IL-4,and IL-6 were detected before and after treatment.Results After treatment,the cure rate of the treatment group(87.23%)was significantly higher than that of the control group(70.21%),and the difference was statistically significant(P<0.05).After treatment,the disappearance times of pelvic pain and leucorrhea in the treatment group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the VAS scores of the two groups were significantly decreased,and the VAS score of the treatment group was significantly lower than that of the control group(P<0.05).After treatment,the levels of MMP-9 and IL-6 in two groups were significantly decreased,while the level of IL-4 in two groups was significantly increased(P<0.05).After treatment,the levels of MMP-9 and IL-6 in the treatment group were lower than those in the control group,and the level of IL-4 in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Huangtengsu Capsules combined with Levofloxacin Tablets can improve the clinical efficacy of endometritis and the main symptoms,and regulate the inflammatory reaction,with good safety.