摘要
Alzheimer’s disease(AD)is a neurodegenerative disease characterized by dementia and mental illness.The main pathological changes of AD are the accumulation of amyloidβ(Aβ)and phosphorylated tau.With the increase in the aging population,the prevalence among adults aged≥60 years will be growing from 5.4%(2015)to 6.7%(2050)in China.[1]At the present stage,the diagnosis of AD is primarily based on the long term clinical observation.Neuro-imaging and invasive cerebrospinal fluid(CSF)measurement of Aβand tau may help making a differential diagnosis,but the cost to conduct these examinations is high and they are only applicable for the middle to late stages of the disease.
