Micropillar-arrayed surfaces promote transforming growth factor beta 1 induced epithelial to mesenchymal transition by focal adhesion kinase-related signaling in A549 cells

To the Editor:Substrate rigidity and topography are two important biomechanical factors that can modulate the biological behavior of cancer cells such as epithelial to mesenchymal transition(EMT).Currently,although studies have begun to focus on how the mechanical microenvironment determines the fate of multiple cells,the mechanism of the mechanical microenvironment affecting EMT is still unclear.