中青年女性颈椎椎旁肌群体质成分与骨密度的相关性分析

Analysis of the correlation between body composition of paraspinal cervical muscle and bone mineral density in young and middle-aged women

目的探讨中青年女性颈椎椎旁肌群体质成分与骨密度的相关关系。方法招募218名21~59岁的成年女性进行颈部定量CT(QCT)检查,测量C6椎体骨密度(BMD)及C6椎体中心层面椎旁肌群横截面积(cross-sectional area,CSA)和平均CT值。检验样本正态性,使用方差分析比较各样本均数。使用组内相关系数(interclass correlation coefficient,ICC)评价测量重复性。使用偏相关分析研究颈椎椎旁肌群与骨密度的相关关系。结果C6水平椎旁肌群CSA与年龄(r=0.142,P<0.05)、体质指数(BMI)(r=0.575,P<0.01)呈正相关关系,椎旁肌群密度与年龄、BMI无显著相关性。BMD与年龄呈负相关(r=-0.179,P<0.01),与BMI无显著相关性。控制年龄、BMI因素,C6水平椎旁肌群CSA与BMD无显著相关性,平均CT值与BMD呈正相关(P<0.01)。结论中青年女性颈椎椎旁肌群脂肪浸润程度与BMD存在相关性。

Objective To investigate the correlation between cervical paravertebral muscle composition and bone mineral density of in young and middle-age women.Methods Two hundred and eighteen adult women aged from 21 to 59 years old were recruited to conduct the neck quantitative computed tomography(QCT)scanning.The cross-sectional area(CSA)and average CT values of paravertebral muscle group and bone mineral density(BMD)at the C6 central plane were measured.The sample normality was tested.The means of the samples were compared using ANOVA.The interclass correlation coefficient(ICC)was used to evaluate measurement reproducibility.The correlation between paravertebral muscle group and BMD was studied with partial correlation analysis.Results Paravertebral muscle group CSA at C6 level was positively correlated with age(r=0.142,P<0.05)and body mass index(BMI,r=0.575,P<0.01).Paravertebral muscle group density was not significantly correlated with age or BMI.BMD was negatively correlated with age(r=-0.179,P<0.01),and there was no significant correlation with BMI.After adjusting age and BMI,there was no significant correlation between paravertebral muscle group CSA and BMD at C6 level,but the mean CT value was positively correlated with BMD(P<0.01).Conclusion The degree of fat infiltration in the cervical paravertebral muscle group is associated with BMD in young and middle-aged women.