动物模型在肩袖损伤研究中的应用

Animal models for study on rotator cuff injury

肩袖损伤是肩关节疼痛和功能障碍的最常见原因。理想的肩关节动物模型应具有与人相近的解剖结构和功能,并能模拟肌腱损伤后的微环境变化。目前已有大鼠、小鼠、兔、羊、犬、牛和非人灵长类动物等多种动物模型被用于研究肩袖损伤的机制、不同修复方法的效果以及影响腱骨愈合的因素。虽然大动物模型在解剖结构上与人更为相近,但是小动物模型在揭示肩袖损伤和愈合的生物学机制方面更具优势。针对研究目标选择合适的动物模型,以及建立新的小动物模型,对探究肩袖疾病机制及研发新的治疗策略至关重要。

Rotator cuff injuries are the most common cause of shoulder pain and dysfunction.Ideal animal shoulder models should have similar shoulder anatomy and function as human,and are able to replicate the microenvironment change after tendon injury.At present,a variety of animal models including rat,mouse,rabbit,sheep,canine,bovine,and primate have been used to study the mechanism of rotator cuff injury,effects of different repair techniques,and factors affecting tendon to bone healing.Although large animal models are more anatomically similar to humans,small animal models are more convenient in revealing the biological mechanism of rotator cuff injury and healing.Choosing appropriate animal models based on research objectives and establishing new small animal models play a critical role in revealing the mechanism of rotator cuff diseases and developing novel treating strategies.